TY  -  
T1  - Nanosized silver, but not titanium dioxide or zinc oxide, enhances oxidative stress and inflammatory response by inducing 5-HETE activation in THP-1 cells 
SN  -  /  
UR  - http://hdl.handle.net/10138/322027 
T3  -  
A1  - Poon, Wing-Lam; Lee, Jetty Chung-Yung; Leung, Kin Sum; Alenius, Harri; El-Nezami, Hani; Karisola, Piia 
A2  -  
PB  -  
Y1  - 2020 
LA  - eng 
AB  - Bioactive, oxygenated metabolites of polyunsaturated fatty acids (PUFAs) are important indicators of inflammation and oxidative stress but almost nothing is known about their interactions with nanomaterials (NMs). To investigate the effects of nano-sized materials (n-TiO2, n-ZnO, n-Ag) and their bulk-sized or ionic (b-TiO2, b-ZnO, i-Ag) counterpart, we studied the status of oxidative stress and PUFA metabolism in THP-1 cells at low-toxic concentrations (... 
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IS  -  
SP  -  
OP  -  
KW  - Nanoparticles; metal oxides; fatty acid metabolism; LC; MS; microarray analysis; GLUTATHIONE; NANOPARTICLES; METAL; NANOTOXICITY; TRANSPORTERS; MACROPHAGES; HOMEOSTASIS; METABOLISM; MONOCYTES; TOXICITY; 3111 Biomedicine 
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ER  -