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T1  - Neuroinflammatory Triangle Presenting Novel Pharmacological Targets for Ischemic Brain Injury 
SN  -  /  
UR  - http://hdl.handle.net/10138/336967 
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A1  - Shaheryar, Zaib A.; Khan, Mahtab A.; Adnan, Ch. Sherjeel; Zaidi, Awais Ali; Hänggi, Daniel; Muhammad, Sajjad 
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Y1  - 2021 
LA  - eng 
AB  - Ischemic stroke is one of the leading causes of morbidity and mortality globally. Hundreds of clinical trials have proven ineffective in bringing forth a definitive and effective treatment for ischemic stroke, except a myopic class of thrombolytic drugs. That, too, has little to do with treating long-term post-stroke disabilities. These studies proposed diverse options to treat stroke, ranging from neurotropic interpolation to venting antioxidant activity, from blocking specific receptors to obs... 
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KW  - neuroinflammation; blood brain barrier; cytokine; brain microvascular endothelial cell; reactive oxidative species; NF-KAPPA-B; NECROSIS-FACTOR-ALPHA; NITRIC-OXIDE SYNTHASE; CENTRAL-NERVOUS-SYSTEM; NEUROTROPHIC FACTOR EXPRESSION; OXIDATIVE STRESS; IFN-GAMMA; ENDOTHELIAL-CELLS; SIGNALING PATHWAY; GROWTH-FACTOR; 3112 Neurosciences; 3121 General medicine, internal medicine and other clinical medicine 
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