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T1  - Neuronal Dynamics and miRNA Signaling Differ between SH-SY5Y APPSwe and PSEN1 Mutant iPSC-Derived AD Models upon Modulation with miR-124 Mimic and Inhibitor 
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UR  - http://hdl.handle.net/10138/334602 
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A1  - Garcia, Gonçalo; Pinto, Sara; Cunha, Mar; Fernandes, Adelaide; Koistinaho, Jari; Brites, Dora 
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PB  - Multidisciplinary Digital Publishing Institute 
Y1  - 2021 
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AB  - Neuronal miRNA dysregulation may have a role in the pathophysiology of Alzheimer’s disease (AD). miRNA(miR)-124 is largely abundant and a critical player in many neuronal functions. However, the lack of models reliably recapitulating AD pathophysiology hampers our understanding of miR-124’s role in the disease. Using the classical human SH-SY5Y-<i>APP695 Swedish</i> neuroblastoma cells (SH-<i>SWE</i>) and the <i>PSEN1</i> mutant iPSC-derived neurons (iNEU-<i>PSEN</i>), we observed a sustained up... 
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