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T1  - Neuronal Dynamics and miRNA Signaling Differ between SH-SY5Y APPSwe and PSEN1 Mutant iPSC-Derived AD Models upon Modulation with miR-124 Mimic and Inhibitor 
SN  -  /  
UR  - http://hdl.handle.net/10138/335751 
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A1  - Garcia, Goncalo; Pinto, Sara; Cunha, Mar; Fernandes, Adelaide; Koistinaho, Jari; Brites, Dora 
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Y1  - 2021 
LA  - eng 
AB  - Neuronal miRNA dysregulation may have a role in the pathophysiology of Alzheimer's disease (AD). miRNA(miR)-124 is largely abundant and a critical player in many neuronal functions. However, the lack of models reliably recapitulating AD pathophysiology hampers our understanding of miR-124's role in the disease. Using the classical human SH-SY5Y-APP695 Swedish neuroblastoma cells (SH-SWE) and the PSEN1 mutant iPSC-derived neurons (iNEU-PSEN), we observed a sustained upregulation of miR-124/miR-12... 
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KW  - Alzheimer's disease (AD); cell experimental models; inflammatory-associated miRNAs; iPSC-derived neurons; miR-124-3p modulation; neuronal dysfunction; neuropathological hallmarks of AD; paracrine signaling; secretome; small extracellular vesicles (exosomes); ALZHEIMERS-DISEASE; NEURITE OUTGROWTH; TAU-PROTEIN; CELLS; DIFFERENTIATION; MICRORNAS; HYPERPHOSPHORYLATION; TRANSFECTION; EXPRESSION; APOPTOSIS; 3112 Neurosciences; 1182 Biochemistry, cell and molecular biology 
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