TY - T1 - Neuronal ICAM-5 Inhibits Microglia Adhesion and Phagocytosis and Promotes an Anti-inflammatory Response in LPS Stimulated Microglia SN - / UR - http://hdl.handle.net/10138/232438 T3 - A1 - Paetau, Sonja; Rolova, Taisia; Ning, Lin; Gahmberg, Carl G. A2 - PB - Y1 - 2017 LA - eng AB - The intercellular adhesion molecule-5 (ICAM-5) regulates neurite outgrowth and synaptic maturation. ICAM-5 overexpression in the hippocampal neurons induces filopodia formation in vitro. Since microglia are known to prune supernumerous synapses during development, we characterized the regulatory effect of ICAM-5 on microglia. ICAM-5 was released as a soluble protein from N-methyl-D-aspartic acid (NMDA)-treated neurons and bound by microglia. ICAM-5 promoted down-regulation of adhesion and phagoc... VO - IS - SP - OP - KW - ICAM-5; microglia; adhesion; phagocytosis; TNF-alpha; ICAM-1; integrin; SPINE MATURATION; LEUKOCYTE INTEGRIN; ALPHA-ACTININ; TELENCEPHALIN; MOLECULE; BINDING; GLYCOPROTEIN; ACTIVATION; CD11A/CD18; OUTGROWTH; 1182 Biochemistry, cell and molecular biology N1 - PP - ER -