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T1  - Neuronal ICAM-5 Inhibits Microglia Adhesion and Phagocytosis and Promotes an Anti-inflammatory Response in LPS Stimulated Microglia 
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UR  - http://hdl.handle.net/10138/232438 
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A1  - Paetau, Sonja; Rolova, Taisia; Ning, Lin; Gahmberg, Carl G. 
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Y1  - 2017 
LA  - eng 
AB  - The intercellular adhesion molecule-5 (ICAM-5) regulates neurite outgrowth and synaptic maturation. ICAM-5 overexpression in the hippocampal neurons induces filopodia formation in vitro. Since microglia are known to prune supernumerous synapses during development, we characterized the regulatory effect of ICAM-5 on microglia. ICAM-5 was released as a soluble protein from N-methyl-D-aspartic acid (NMDA)-treated neurons and bound by microglia. ICAM-5 promoted down-regulation of adhesion and phagoc... 
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KW  - ICAM-5; microglia; adhesion; phagocytosis; TNF-alpha; ICAM-1; integrin; SPINE MATURATION; LEUKOCYTE INTEGRIN; ALPHA-ACTININ; TELENCEPHALIN; MOLECULE; BINDING; GLYCOPROTEIN; ACTIVATION; CD11A/CD18; OUTGROWTH; 1182 Biochemistry, cell and molecular biology 
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