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T1  - Neutrophil activation in septic acute kidney injury : A post hoc analysis of the FINNAKI study 
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UR  - http://hdl.handle.net/10138/312955 
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A1  - Törnblom, Sanna; Nisula, Sara; Vaara, Suvi T.; Poukkanen, Meri; Andersson, Sture; Pettilä, Ville; Pesonen, Eero 
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Y1  - 2019 
LA  - eng 
AB  - Background Inflammation, reflected by high plasma interleukin-6 concentration, is associated with acute kidney injury (AKI) in septic patients. Neutrophil activation has pathophysiological significance in experimental septic AKI. We hypothesized that neutrophil activation is associated with AKI in critically ill sepsis patients. Methods We measured plasma (n = 182) and urine (n = 118) activin A (a rapidly released cytosolic neutrophil protein), interleukin-8 (a chemotactic factor for neutrophils... 
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KW  - activin A; acute kidney injury; critical illness; intensive care; interleukin-6; interleukin-8; myeloperoxidase; sepsis; ACUTE-RENAL-FAILURE; HEPARIN-BINDING PROTEIN; NECROSIS-FACTOR-ALPHA; ACTIVIN-A RELEASE; SEPSIS; SERUM; INFLAMMATION; FOLLISTATIN; MORTALITY; ENDOTOXEMIA; 3126 Surgery, anesthesiology, intensive care, radiology 
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