TY  -  
T1  - Neutrophil extracellular trap formation requires OPA1-dependent glycolytic ATP production 
SN  -  /  
UR  - http://hdl.handle.net/10138/238496 
T3  -  
A1  - Amini, Poorya; Stojkov, Darko; Felser, Andrea; Jackson, Christopher B.; Courage, Carolina; Schaller, Andre; Gelman, Laurent; Soriano, Maria Eugenia; Nuoffer, Jean-Marc; Scorrano, Luca; Benarafa, Charaf; Yousefi, Shida; Simon, Hans-Uwe 
A2  -  
PB  -  
Y1  - 2018 
LA  - eng 
AB  - Optic atrophy 1 (OPA1) is a mitochondrial inner membrane protein that has an important role in mitochondrial fusion and structural integrity. Dysfunctional OPA1 mutations cause atrophy of the optic nerve leading to blindness. Here, we show that OPA1 has an important role in the innate immune system. Using conditional knockout mice lacking Opa1 in neutrophils (Opa1(N Delta)), we report that lack of OPA1 reduces the activity of mitochondrial electron transport complex I in neutrophils. This then c... 
VO  -  
IS  -  
SP  -  
OP  -  
KW  - DOMINANT OPTIC ATROPHY; MITOCHONDRIAL-DNA; OPA1 MUTATIONS; BACTERIAL CLEARANCE; SKELETAL-MUSCLE; NADPH OXIDASE; FUSION; RELEASE; DEGRANULATION; METABOLISM; 3111 Biomedicine 
N1  -   
PP  -  
ER  -