TY  -  
T1  - New N-phenyl-4,5-dibromopyrrolamides as DNA gyrase B inhibitors 
SN  -  /  
UR  - http://hdl.handle.net/10138/315658 
T3  -  
A1  - Zidar, Nace; Macut, Helena; Tomašič, Tihomir; Peterlin Mašič, Lucija; Ilaš, Janez; Zega, Anamarija; Tammela, Päivi; Kikelj, Danijel 
A2  -  
PB  -  
Y1  - 2019 
LA  - eng 
AB  - Due to the rapid development of antimicrobial resistance, the discovery of new antibacterials is essential in the fight against potentially lethal infections. The DNA gyrase B (GyrB) subunit of bacterial DNA gyrase is an excellent target for the design of antibacterials, as it has been clinically validated by novobiocin. However, there are currently no drugs in clinical use that target GyrB. We prepared a new series of N-phenyl-4,5-dibromopyrrolamides and evaluated them against DNA gyrase and ag... 
VO  -  
IS  -  
SP  -  
OP  -  
KW  - 1182 Biochemistry, cell and molecular biology; 116 Chemical sciences; 317 Pharmacy; N-PHENYLPYRROLAMIDES; ATPASE INHIBITORS; DRUG DISCOVERY; ANTIBACTERIAL; TOPOISOMERASE; PHENYLINDOLAMIDES; OPTIMIZATION; CANDIDATE; DESIGN 
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ER  -