TY  -  
T1  - New tricks of prolyl oligopeptidase inhibitors - A common drug therapy for several neurodegenerative diseases 
SN  -  /  
UR  - http://hdl.handle.net/10138/312566 
T3  -  
A1  - Svarcbahs, Reinis; Julku, Ulrika; Kilpelainen, Tommi; Kyyrö, Mirva; Jäntti, Maria; Myohänen, Timo T. 
A2  -  
PB  -  
Y1  - 2019 
LA  - eng 
AB  - Changes in prolyl oligopeptidase (PREP) expression levels, protein distribution, and activity correlate with aging and are reported in many neurodegenerative conditions. Together with decreased neuropeptide levels observed in aging and neurodegeneration, and PREP's ability to cleave only small peptides, PREP was identified as a druggable target. Known PREP non-enzymatic functions were disregarded or attributed to PREP enzymatic activity, and several potent small molecule PREP inhibitors were dev... 
VO  -  
IS  -  
SP  -  
OP  -  
KW  - Neurodegeneration; Aipha-synuclein; Tau protein; Amyloid-beta; Autophagy; Serine protease; POSTPROLINE CLEAVING ENZYME; SUBSTRATE-GATING MECHANISM; ALPHA-SYNUCLEIN; ENDOPEPTIDASE INHIBITOR; PARKINSONS-DISEASE; ACTIVE-SITE; TAU-PROTEIN; ARGININE-VASOPRESSIN; MOLECULAR-DYNAMICS; MOTOR BEHAVIOR; 317 Pharmacy 
N1  -   
PP  -  
ER  -