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T1  - Next generation organoids for biomedical research and applications 
SN  -  /  
UR  - http://hdl.handle.net/10138/327408 
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A1  - Lou, Yan-Ru; Leung, Alan W. 
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Y1  - 2018 
LA  - eng 
AB  - Organoids are in vitro cultures of miniature fetal or adult organ-like structures. Their potentials for use in tissue and organ replacement, disease modeling, toxicology studies, and drug discovery are tremendous. Currently, major challenges facing human organoid technology include (i) improving the range of cellular heterogeneity for a particular organoid system, (ii) mimicking the native micro- and matrix-environment encountered by cells within organoids, and (iii) developing robust protocols ... 
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KW  - Organoids; Human; Reverse engineering; Self-organization; Designer matrix; Niche factors; Pluripotent stem cells; Drug screening; Disease modeling; Transplantation; PLURIPOTENT STEM-CELLS; IN-VITRO EXPANSION; DISSOCIATED EMBRYONIC CHICK; HUMAN CEREBRAL ORGANOIDS; NEURAL CREST INDUCTION; ADVERSE DRUG-REACTIONS; FUNCTIONAL HUMAN LIVER; HEPATOCYTE-LIKE CELLS; EX-VIVO EXPANSION; EXTRACELLULAR-MATRIX; 317 Pharmacy 
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