TY  -  
T1  - Non-cell-based in vitro methods in the study of prodrug absorption and metabolism 
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UR  - URN:NBN:fi-fe201801151289; http://hdl.handle.net/10138/153220 
T3  -  
A1  - Tervahauta, Tuomas 
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PB  - Helsingfors universitet 
Y1  - 2015 
LA  - eng 
AB  - Prodrugs are pharmacologically inactive molecules which undergo metabolic bioactivation in vivo to form pharmaceutically active agents. Prodrugs have been designed to improve so called drug-like properties of active parent compounds (APC) i.e. to increase solubility or absorption and to reduce first-pass metabolism etc. In this master's thesis the goal was to establish non-cell-based in vitro methods to study prodrug bioactivation. 

Four commercially available prodrugs (bambuterol, olmesartan m... 
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KW  - PAMPA; prodrug; bioactivation; absorption; metabolism; S9 fractions; LC-MS/MS; aihiolääke; bioaktivaatio; imeytyminen; metabolia; S9-fraktio; Biofarmaci; Biopharmacy; Biofarmasia 
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