TY  -  
T1  - Nrf2/Keap1 Pathway and Expression of Oxidative Stress Lesions 8-hydroxy-2 '-deoxyguanosine and Nitrotyrosine in Melanoma 
SN  -  /  
UR  - http://hdl.handle.net/10138/163560 
T3  -  
A1  - Hintsala, Hanna-Riikka; Jokinen, Elina; Haapasaari, Kirsi-Maria; Moza, Monica; Ristimaki, Ari; Soini, Ylermi; Koivunen, Jussi; Karihtala, Peeter 
A2  -  
PB  -  
Y1  - 2016 
LA  - eng 
AB  - Background/Aim: Increased expression and prognostic significance of major redox regulator nuclear factor erythroid-2-related factor (Nrf2) is recognized in many cancers. Our aim was to investigate the role of oxidative stress markers in melanoma. Materials and Methods: We characterized the immunohistochemical expression of Nrf2, kelch-like ECH-associated protein 1 (Keap1), BRAF(V600E), 8-hydroxy-2'-deoxyguanosine (8-OHdG) and nitrotyrosine in 36 nevi, 14 lentigo maligna and 71 malignant melanoma... 
VO  -  
IS  -  
SP  -  
OP  -  
KW  - BRAF; Keap1; melanoma; nitrotyrosine; Nrf2; oxidative stress; 8-OHdG; CLINICOPATHOLOGICAL FEATURES; NRF2 EXPRESSION; POOR SURVIVAL; CANCER; 8-HYDROXYDEOXYGUANOSINE; CARCINOGENESIS; DAMAGE; MICROENVIRONMENT; INHIBITOR; 3122 Cancers 
N1  -   
PP  -  
ER  -