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T1  - Nuclear factor E2-related factor 2 deficiency impairs atherosclerotic lesion development but promotes features of plaque instability in hypercholesterolaemic mice 
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UR  - http://hdl.handle.net/10138/311312 
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A1  - Ruotsalainen, Anna-Kaisa; Lappalainen, Jari P.; Heiskanen, Emmi; Merentie, Mari; Sihvola, Virve; Näpänkangas, Juha; Lottonen-Raikaslehto, Line; Kansanen, Emilia; Adinolfi, Simone; Kaarniranta, Kai; Ylä-Herttuala, Seppo; Jauhiainen, Matti; Pirinen, Eija; Levonen, Anna-Liisa 
A2  -  
PB  -  
Y1  - 2019 
LA  - eng 
AB  - Aims Oxidative stress and inflammation play an important role in the progression of atherosclerosis. Transcription factor NF-E2-related factor 2 (Nrf2) has antioxidant and anti-inflammatory effects in the vessel wall, but paradoxically, global loss of Nrf2 in apoE deficient mice alleviates atherosclerosis. In this study, we investigated the effect of global Nrf2 deficiency on early and advanced atherogenesis in alternative models of atherosclerosis, LDL receptor deficient mice (LDLR-/-), and LDL... 
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KW  - Nrf2; MONOCYTE CHEMOATTRACTANT PROTEIN-1; LOW-DENSITY-LIPOPROTEIN; APOLIPOPROTEIN-E; CHOLESTEROL TRANSPORT; NRF2; EXPRESSION; GROWTH; DIET; SUSCEPTIBILITY; PROGRESSION; Oxidative stress; Inflammation; Atherosclerosis; Plaque instability; 3111 Biomedicine 
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