TY  -  
T1  - O-GlcNAc transferase couples MRE11 to transcriptionally active chromatin to suppress DNA damage 
SN  -  /  
UR  - http://hdl.handle.net/10138/341263 
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A1  - Gondane, Aishwarya; Girmay, Samuel; Helevä, Alma; Pallasaho, Satu; Loda, Massimo; Itkonen, Harri M. 
A2  -  
PB  -  
Y1  - 2022 
LA  - eng 
AB  - Background: Transcription, metabolism and DNA damage response are tightly regulated to preserve the genomic integrity, and O-GlcNAc transferase (OGT) is positioned to connect the three. Prostate cancer is the most common cancer in men, and androgen-ablation therapy halts disease progression. However, a significant number of prostate cancer patients develop resistance against anti-androgens, and this incurable disease is termed castration-resistant prostate cancer (CRPC). We have shown that combi... 
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OP  -  
KW  - CDK9 INHIBITION; Castration-resistant prostate cancer; Cyclin-dependent kinase 9; DNA damage; EXPRESSION; GLCNACYLATION; GLYCOSYLATION; MRE11; MYC; O-GlcNAc transferase; PROLIFERATION; PROSTATE-CANCER; RECRUITMENT; REPAIR; 3111 Biomedicine; 1182 Biochemistry, cell and molecular biology 
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ER  -