TY  -  
T1  - ORP2 couples LDL-cholesterol transport to FAK activation by endosomal cholesterol/PI(4,5)P-2 exchange 
SN  -  /  
UR  - http://hdl.handle.net/10138/335038 
T3  -  
A1  - Takahashi, Kohta; Kanerva, Kristiina; Vanharanta, Lauri; Almeida-Souza, Leonardo; Lietha, Daniel; Olkkonen, Vesa M.; Ikonen, Elina 
A2  -  
PB  -  
Y1  - 2021 
LA  - eng 
AB  - Low-density lipoprotein (LDL)-cholesterol delivery from late endosomes to the plasma membrane regulates focal adhesion dynamics and cell migration, but the mechanisms controlling it are poorly characterized. Here, we employed auxin-inducible rapid degradation of oxysterol-binding protein-related protein 2 (ORP2/OSBPL2) to show that endogenous ORP2 mediates the transfer of LDL-derived cholesterol from late endosomes to focal adhesion kinase (FAK)-/integrin-positive recycling endosomes in human ce... 
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OP  -  
KW  - cholesterol trafficking; focal adhesion kinase; oxysterol-binding protein-related protein; phosphoinositides; recycling; LOW-DENSITY-LIPOPROTEIN; INTEGRIN ACTIVATION; PLASMA-MEMBRANE; HEARING-LOSS; TRAFFICKING; NPC1; PROTEIN; OSBPL2; COMPLEXES; TRIGGERS; 1182 Biochemistry, cell and molecular biology 
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PP  -  
ER  -