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T1  - Obesity Is Associated With Low NAD+/SIRT Pathway Expression in Adipose Tissue of BMI-Discordant Monozygotic Twins 
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UR  - URN:NBN:fi:hulib-201611243086; http://hdl.handle.net/10138/169760 
T3  -  
A1  - Jukarainen, Sakari; Heinonen, Sini; Rämö, Joel; Rinnankoski-Tuikka, Rita; Rappou, Elisabeth; Tummers, Mark; Muniandy, Maheswary; Hakkarainen, Antti; Lundbom, Jesper; Lundbom, Nina; Kaprio, Jaakko; Rissanen, Aila; Pirinen, Eija; Pietiläinen, Kirsi 
A2  -  
PB  - Helsingfors universitet 
Y1  - 2016 
LA  - eng 
AB  - Context: Sirtuins (SIRTs) regulate cellular metabolism and mitochondrial function according to the energy state of the cell reflected by NAD+‚ levels.


Objective: Our aim was to determine whether expressions of SIRTs and NAD+‚ biosynthesis genes are affected by acquired obesity and how possible alterations are connected with metabolic dys-function while controlling for genetic and familial factors.


Design and Participants: We studied a cross-sectional sample of 40 healthy pairs of monozygotic... 
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KW  - Twin study; Obesity; Sirtuins; Subcutaneous adipose tissue; Internal Medicine; Sisätaudit; Inre medicin 
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ER  -