TY  -  
T1  - Ocular pharmacokinetics of atenolol, timolol and betaxolol cocktail : Tissue exposures in the rabbit eye 
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UR  - http://hdl.handle.net/10138/333103 
T3  -  
A1  - Fayyaz, Anam; Vellonen, Kati-Sisko; Ranta, Veli-Pekka; Toropainen, Elisa; Reinisalo, Mika; Valtari, Annika; Puranen, Jooseppi; Ricci, Giuseppe D'Amico; Heikkinen, Emma M.; Gardner, Iain; Ruponen, Marika; Urtti, Arto; Jamei, Masoud; Amo, Eva M. del 
A2  -  
PB  -  
Y1  - 2021 
LA  - eng 
AB  - Quantitative understanding of pharmacokinetics of topically applied ocular drugs requires more research to further understanding and to eventually allow predictive in silico models to be developed. To this end, a topical cocktail of betaxolol, timolol and atenolol was instilled on albino rabbit eyes. Tear fluid, corneal epithelium, corneal stroma with endothelium, bulbar conjunctiva, anterior sclera, iris-ciliary body, lens and vitreous samples were collected and analysed using LC-MS/MS. Iris-ci... 
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KW  - Timolol; Betaxolol; Atenolol; Ocular pharmacokinetics; Rabbit; Topical; Intracameral; Corneal route; Conjunctival-scleral route; SYSTEMIC ABSORPTION; BETA-BLOCKERS; PENETRATION ROUTES; DRUG DIFFUSION; CONJUNCTIVAL; PERMEABILITY; PILOCARPINE; CORNEAL; FLUORESCEIN; CLEARANCE; 317 Pharmacy 
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