TY  -  
T1  - Olfactomedin-4 improves cutaneous wound healing by promoting skin cell proliferation and migration through POU5F1/OCT4 and ESR1 signalling cascades 
SN  -  /  
UR  - http://hdl.handle.net/10138/342293 
T3  -  
A1  - Klaas, Mariliis; Maemets-Allas, Kristina; Heinmäe, Elizabeth; Lagus, Heli; Arak, Terje; Eller, Mart; Kingo, Kulli; Kankuri, Esko; Jaks, Viljar 
A2  -  
PB  -  
Y1  - 2022 
LA  - eng 
AB  - Olfactomedin-4 (OLFM4) is an olfactomedin-domain-containing glycoprotein, which regulates cell adhesion, proliferation, gastrointestinal inflammation, innate immunity and cancer metastasis. In the present study we investigated its role in skin regeneration. We found that OLFM4 expression is transiently upregulated in the proliferative phase of cutaneous wound healing in humans as well as in mice. Moreover, a significant increase in OLFM4 expression was detected in the skin of lesional psoriasis,... 
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IS  -  
SP  -  
OP  -  
KW  - Skin regeneration; Wound healing; Skin burns; Olfactomedin-4; Keratinocytes; Psoriasis; INNATE IMMUNITY; STEM-CELLS; FAMILY; EXPRESSION; MARKER; HGC-1; GENE; APOPTOSIS; ESTROGEN; MODELS; 1182 Biochemistry, cell and molecular biology 
N1  -   
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ER  -