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T1  - Oncolytic Adenovirus ORCA-010 Activates Proinflammatory Myeloid Cells and Facilitates T Cell Recruitment and Activation by PD-1 Blockade in Melanoma 
SN  -  /  
UR  - http://hdl.handle.net/10138/328961 
T3  -  
A1  - Milenova, Ioanna; Gonzalez, Marta Lopez; Quixabeira, Dafne C. A.; Santos, Joao Manuel; Cervera-Carrascon, Victor; Dong, Wenliang; Hemminki, Akseli; van Beusechem, Victor W.; van de Ven, Rieneke; de Gruijl, Tanja D. 
A2  -  
PB  -  
Y1  - 2021 
LA  - eng 
AB  - Immune checkpoint inhibitors have advanced the treatment of melanoma. Nevertheless, a majority of patients are resistant, or develop resistance, to immune checkpoint blockade, which may be related to prevailing immune suppression by myeloid regulatory cells in the tumor microenvironment (TME). ORCA-010 is a novel oncolytic adenovirus that selectively replicates in, and lyses, cancer cells. We previously showed that ORCA-010 can activate melanoma-exposed conventional dendritic cells (cDCs). To st... 
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IS  -  
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OP  -  
KW  - oncolytic adenovirus; macrophages; T cells; immune checkpoint inhibition; melanoma; 318 Medical biotechnology; 11832 Microbiology and virology; 1184 Genetics, developmental biology, physiology 
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