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T1  - Oncolytic adenovirus shapes the ovarian tumor microenvironment for potent tumor-infiltrating lymphocyte tumor reactivity 
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UR  - http://hdl.handle.net/10138/310485 
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A1  - Santos, João Manuel; Heiniö, Camilla; Cervera-Carrascon, Victor; Quixabeira, Dafne C A; Siurala, Mikko; Havunen, Riikka; Butzow, Ralf; Zafar, Sadia; de Gruijl, Tanja; Lassus, Heini; Kanerva, Anna; Hemminki, Akseli 
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PB  -  
Y1  - 2020 
LA  - eng 
AB  - BACKGROUND: Ovarian cancers often contain significant numbers of tumor-infiltrating lymphocytes (TILs) that can be readily harnessed for adoptive T-cell therapy (ACT). However, the immunosuppressive ovarian tumor microenvironment and lack of tumor reactivity in TILs can limit the effectiveness of the therapy. We hypothesized that by using an oncolytic adenovirus (Ad5/3-E2F-D24-hTNFa-IRES-hIL2; TILT-123) to deliver tumor necrosis factor alpha (TNFa) and interleukin-2 (IL-2), we could counteract i... 
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KW  - 3111 Biomedicine; TIL therapy; adenovirus; immunotherapy; oncolytic virus; tumor microenvironment; tumor-infiltrating lymphocytes; CANCER-CELLS; IMMUNE-RESPONSE; PD-L1 EXPRESSION; NECROSIS-FACTOR-ALPHA; ADOPTIVE CELL THERAPY; METASTATIC MELANOMA; FAVORABLE PROGNOSIS; IN-VIVO; REGULATORY T-CELLS; COMPLETE RESPONSES 
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