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T1  - Opposite Expression Patterns of Spry3 and p75NTR in Cerebellar Vermis Suggest a Male-Specific Mechanism of Autism Pathogenesis 
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UR  - http://hdl.handle.net/10138/311187 
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A1  - Ning, Zhenfei; Williams, John M.; Kumari, Romika; Baranov, Pavel; Moore, Tom 
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Y1  - 2019 
LA  - eng 
AB  - Autism is a genetically complex neurobehavioral disorder with a population prevalence of more than 1%. Cerebella abnormalities, including Purkinje cell deficits in the vermis, are consistently reported, and rodent models of cerebellar dysfunction exhibit features analogous to human autism. We previously analyzed the regulation and expression of the pseudoautosomal region 2 gene SPRY3, which is adjacent to X chromosome-linked TMLHE, a known autism susceptibility gene. SPRY3 is a regulator of bran... 
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KW  - autism; cerebellum; SPRY3; p75NTR; pseudoautosomal region; TMLHE; camitine; BETA-SATELLITE DNA; SPECTRUM DISORDER; NEUROTROPHIN RECEPTOR; GENE-EXPRESSION; PURKINJE-CELLS; DEATH RECEPTOR; BRAIN; RISK; CHILDREN; REVEALS; 3124 Neurology and psychiatry 
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