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T1  - Osteoarthritis and Toll-Like Receptors: When Innate Immunity Meets Chondrocyte Apoptosis 
SN  -  /  
UR  - http://hdl.handle.net/10138/316035 
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A1  - Barreto, Goncalo; Manninen, Mikko; Eklund, Kari K. 
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PB  -  
Y1  - 2020 
LA  - eng 
AB  - Osteoarthritis (OA) has long been viewed as a degenerative disease of cartilage, but accumulating evidence indicates that inflammation has a critical role in its pathogenesis. In particular, chondrocyte-mediated inflammatory responses triggered by the activation of innate immune receptors by alarmins (also known as danger signals) are thought to be involved. Thus, toll-like receptors (TLRs) and their signaling pathways are of particular interest. Recent reports suggest that among the TLR-induced... 
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KW  - ACTIVATION; CELL-DEATH; EXPRESSION; FIBRONECTIN FRAGMENTS; HUMAN ARTICULAR-CARTILAGE; KNEE OSTEOARTHRITIS; NITRIC-OXIDE; PROTEOGLYCANS DECORIN; RHEUMATOID-ARTHRITIS; SIGNALING PATHWAY; apoptosis; cartilage; chondrocytes; innate immunity; osteoarthritis; toll-like receptors; 3121 General medicine, internal medicine and other clinical medicine; 3111 Biomedicine 
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