TY  -  
T1  - Overcoming Drug-resistance in Chronic Myeloid Leukemia 
SN  -  /  
UR  - URN:NBN:fi:hulib-201801191074; http://hdl.handle.net/10138/231375 
T3  -  
A1  - Rebane, Anni 
A2  -  
PB  - Helsingin yliopisto 
Y1  - 2015 
LA  - eng 
AB  - Given the success of first-line treatment in chronic myeloid leukemia (CML), the prevalence of the disease is estimated to increase and more patients are expected to develop resistance to therapy. Thus, even relatively rare point mutations are likely to become more common. In CML, the uncontrollable division of myeloid cells is caused by a reciprocal translocation of chromosomes 9 and 22, resulting in the Philadelphia chromosome. At the meeting point of the two chromosomes, breakpoint cluster re... 
VO  -  
IS  -  
SP  -  
OP  -  
KW  - BCR-ABL1; T315I; T315M; E255V/T315I; Chronic myeloid leukemia; CML; leukemia; drug-resistance; point mutations; high-throughput screening; combination testing; Cancer 
N1  -   
PP  -  
ER  -