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T1  - PSEN1ΔE9, APPswe, and APOE4 Confer Disparate Phenotypes in Human iPSC-Derived Microglia 
SN  -  /  
UR  - http://hdl.handle.net/10138/312606 
T3  -  
A1  - Konttinen, Henna; Cabral-da-Silva, Mauricio e Castro; Ohtonen, Sohvi; Wojciechowski, Sara; Shakirzyanova, Anastasia; Caligola, Simone; Giugno, Rosalba; Ishchenko, Yevheniia; Hernández, Damián; Fazaludeen, Mohammad Feroze; Eamen, Shaila; Budia, Mireia Gómez; Fagerlund, Ilkka; Scoyni, Flavia; Korhonen, Paula; Huber, Nadine; Haapasalo, Annakaisa; Hewitt, Alex W.; Vickers, James; Smith, Grady C.; Oksanen, Minna; Graff, Caroline; Kanninen, Katja M.; Lehtonen, Sarka; Propson, Nicholas; Schwartz, Michael P.; Pébay, Alice; Koistinaho, Jari; Ooi, Lezanne; Malm, Tarja 
A2  -  
PB  -  
Y1  - 2019 
LA  - eng 
AB  - Summary Here we elucidate the effect of Alzheimer disease (AD)-predisposing genetic backgrounds, APOE4, PSEN1ΔE9, and APPswe, on functionality of human microglia-like cells (iMGLs). We present a physiologically relevant high-yield protocol for producing iMGLs from induced pluripotent stem cells. Differentiation is directed with small molecules through primitive erythromyeloid progenitors to re-create microglial ontogeny from yolk sac. The iMGLs express microglial signature genes and respond to A... 
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KW  - Alzheimer disease; iPSC; microglia; phagocytosis; mitochondria; metabolism; PLURIPOTENT STEM-CELLS; ALZHEIMERS-DISEASE; PRECURSOR PROTEIN; BETA; DIFFERENTIATION; MODEL; HEMATOPOIESIS; PRESENILIN-1; MACROPHAGES; ACTIVATION; 1182 Biochemistry, cell and molecular biology; 3111 Biomedicine 
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