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T1  - Palmitate and oleate exert differential effects on insulin signalling and glucose uptake in human skeletal muscle cells 
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UR  - http://hdl.handle.net/10138/225803 
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A1  - Makinen, Selina; Nguyen, Yen H.; Skrobuk, Paulina; Koistinen, Heikki A. 
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Y1  - 2017 
LA  - eng 
AB  - Saturated fatty acids are implicated in the development of insulin resistance, whereas unsaturated fatty acids may have a protective effect on metabolism. We tested in primary human myotubes if insulin resistance induced by saturated fatty acid palmitate can be ameliorated by concomitant exposure to unsaturated fatty acid oleate. Primary human myotubes were pretreated with palmitate, oleate or their combination for 12 h. Glucose uptake was determined by intracellular accumulation of [H-3]-2-deox... 
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KW  - ER stress; fatty acid; glucose uptake; human; insulin signalling; skeletal muscle; FATTY-ACID OXIDATION; RESISTANCE; STRESS; INFLAMMATION; SENSITIVITY; OBESITY; DIET; CARBOHYDRATE; ACCUMULATION; PREVENTION; 3121 General medicine, internal medicine and other clinical medicine 
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