TY - T1 - Panel 3: Genomics, precision medicine and targeted therapies SN - / UR - http://hdl.handle.net/10138/329316 T3 - A1 - Santos-Cortez, R.L.P.; Bhutta, M.F.; Earl, J.P.; Hafrén, Lena; Jennings, M.; Mell, J.C.; Pichichero, M.E.; Ryan, A.F.; Tateossian, Hilda; Ehrlich, G.D. A2 - PB - Y1 - 2020 LA - eng AB - Objective: To review the most recent advances in human and bacterial genomics as applied to pathogenesis and clinical management of otitis media. Data sources: PubMed articles published since the last meeting in June 2015 up to June 2019. Review methods: A panel of experts in human and bacterial genomics of otitis media was formed. Each panel member reviewed the literature in their respective fields and wrote draft reviews. The reviews were shared with all panel members, and a merged draft was c... VO - IS - SP - OP - KW - Genome-wide association study; Metagenomics; Microbiome; Otitis media; Otitis-prone; Precision medicine; amoxicillin; ciprofloxacin; corticosteroid; Haemophilus influenzae vaccine; mannoside; Pneumococcus vaccine; Pneumococcus vaccine 15; Pneumococcus vaccine 20; RNA 16S; unclassified drug; Article; bacterial virulence; disease predisposition; genetic regulation; genomics; Haemophilus infection; health care management; human; immunization; microbial community; microbial genetics; microbiome; nonhuman; otitis media; pathogenesis; personalized medicine; phenotype; pneumococcal infection; priority journal; RNA sequencing; systematic review; animal; genetic predisposition; genetics; microbiology; microflora; middle ear; Animals; Ear, Middle; Genetic Predisposition to Disease; Genomics; Humans; Microbiota; Otitis Media; Precision Medicine; 3125 Otorhinolaryngology, ophthalmology N1 - PP - ER -