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T1  - Part I: Enzyme replacement versus neurotrophic factor viral vector-mediated gene therapy of Parkinson's disease : Part II: The effects of orally dosed tolcapone and entacapone on dopamine metabolism in the dorsal striatum and nucleus accumbens in rats 
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UR  - URN:NBN:fi-fe201801151114; http://hdl.handle.net/10138/24264 
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A1  - Uhari, Johanna 
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PB  - Helsingfors universitet 
Y1  - 2010 
LA  - eng 
AB  - Part I: Parkinson's disease is a slowly progressive neurodegenerative disorder in which particularly the dopaminergic neurons of the substantia nigra pars compacta degenerate and die. Current conventional treatment is based on restraining symptoms but it has no effect on the progression of the disease. Gene therapy research has focused on the possibility of restoring the lost brain function by at least two means: substitution of critical enzymes needed for the synthesis of dopamine and slowing d... 
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KW  - microdialysis; entacapone; tolcapone; dorsal striatum; nucleus accumbens; neurotrophic factor; enzyme replacement strategy; viral vector; Parkinson's disease; mikrodialyysi; entakaponi; tolkaponi; dorsaali striatum; akkumbens-tumake; neurotrofinen tekijä; entsyymikorvaushoito; virusvektori; Parkinsonin tauti; Farmakologi; Pharmacology; Farmakologia 
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