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T1  - Partitioning and Spatial Distribution of Drugs in Ocular Surface Tissues 
SN  -  /  
UR  - http://hdl.handle.net/10138/332741 
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A1  - Balla, Anusha; Auriola, Seppo; Grey, Angus C.; Demarais, Nicholas J.; Valtari, Annika; Heikkinen, Emma M.; Toropainen, Elisa; Urtti, Arto; Vellonen, Kati-Sisko; Ruponen, Marika 
A2  -  
PB  -  
Y1  - 2021 
LA  - eng 
AB  - Ocular drug absorption after eye drop instillation has been widely studied, but partitioning phenomena and spatial drug distribution are poorly understood. We investigated partitioning of seven beta-blocking drugs in corneal epithelium, corneal stroma, including endothelium and conjunctiva, using isolated porcine tissues and cultured human corneal epithelial cells. The chosen beta-blocking drugs had a wide range (-1.76-0.79) of n-octanol/buffer solution distribution coefficients at pH 7.4 (Log D... 
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KW  - cornea; conjunctiva; drug absorption; permeation; beta-blocking agent; MALDI-IMS; SYSTEMIC ABSORPTION; OPHTHALMIC EMULSION; PIGMENTED RABBIT; CORNEAL; PERMEABILITY; CONJUNCTIVAL; PENETRATION; PHARMACOKINETICS; PILOCARPINE; CYCLOSPORINE; 317 Pharmacy 
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