TY  -  
T1  - Perineuronal Net Receptor PTP sigma Regulates Retention of Memories 
SN  -  /  
UR  - http://hdl.handle.net/10138/335163 
T3  -  
A1  - Lesnikova, Angelina; Casarotto, Plinio; Moliner, Rafael; Fred, Senem Merve; Biojone, Caroline; Castren, Eero 
A2  -  
PB  -  
Y1  - 2021 
LA  - eng 
AB  - Perineuronal nets (PNNs) have an important physiological role in the retention of learning by restricting cognitive flexibility. Their deposition peaks after developmental periods of intensive learning, usually in late childhood, and they help in long-term preservation of newly acquired skills and information. Modulation of PNN function by various techniques enhances plasticity and regulates the retention of memories, which may be beneficial when memory persistence entails negative symptoms such... 
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KW  - memory; perineuronal nets; plasticity; PNNs; PTPRS; BDNF; Ntrk2; TrkB; PREFRONTAL CORTEX IMPAIRS; FEAR EXTINCTION; EXTRACELLULAR-MATRIX; ANTIDEPRESSANT DRUGS; NMDA RECEPTORS; MICE LACKING; TRKB; NEURONS; HIPPOCAMPUS; 3112 Neurosciences 
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ER  -