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T1  - Peripheral DNA methylation, cognitive decline and brain aging : pilot findings from the Whitehall II imaging study 
SN  -  /  
UR  - http://hdl.handle.net/10138/235988 
T3  -  
A1  - Chouliaras, Leonidas; Pishva, Ehsan; Haapakoski, Rita; Zsoldos, Eniko; Mahmood, Abda; Filippini, Nicola; Burrage, Joe; Mill, Jonathan; Kivimäki, Mika; Lunnon, Katie; Ebmeier, Klaus P. 
A2  -  
PB  -  
Y1  - 2018 
LA  - eng 
AB  - Aim: The present study investigated the link between peripheral DNA methylation (DNAm), cognitive impairment and brain aging. Methods: We tested the association between blood genome-wide DNAm profiles using the Illumina 450K arrays, cognitive dysfunction and brain MRI measures in selected participants of the Whitehall II imaging sub-study. Results: Eight differentially methylated regions were associated with cognitive impairment. Accelerated aging based on the Hannum epigenetic clock was associa... 
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KW  - brain aging; DNA methylation; epigenetic clock; MCI; mild cognitive impairment; MRI; peripheral biomarker; MESSENGER-RNA EXPRESSION; ALZHEIMERS-DISEASE; INTRON 1; BLOOD; DEMENTIA; TREM2; AGE; DYSREGULATION; HIPPOCAMPUS; ENRICHMENT; 3111 Biomedicine; 3112 Neurosciences; 3124 Neurology and psychiatry 
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