TY - T1 - Persistent human bocavirus 1 infection and tonsillar immune responses SN - / UR - http://hdl.handle.net/10138/335354 T3 - A1 - Ivaska, Lotta E.; Silvoniemi, Antti; Palomares, Oscar; Turunen, Riitta; Mikola, Emilia; Puhakka, Tuomo; Söderlund-Venermo, Maria; Akdis, Mübeccel; Akdis, Cezmi A.; Jartti, Tuomas A2 - PB - Y1 - 2021 LA - eng AB - Background Persistent human bocavirus 1 (HBoV1) infection is a common finding in patients suffering from chronic tonsillar disease. However, the associations between HBoV1 infection and specific immune reactions are not completely known. We aimed to compare in vivo expression of T-cell cytokines, transcription factors, and type I/III interferons in human tonsils between HBoV1-positive and -negative tonsillectomy patients. Methods Tonsil tissue samples, nasopharyngeal aspirate (NPA), and serum sa... VO - IS - SP - OP - KW - cytokine; forkheadbox protein 3; FOXP3; human bocavirus; RAR-related orphan receptor C 2; RORC2; T-helper(17); T-regulatory; tonsil; transcription factor; PARVOVIRUS; CHILDREN; VIRUS; BETA; RNA; 3121 General medicine, internal medicine and other clinical medicine N1 - PP - ER -