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T1  - Pharmacologically diverse antidepressants facilitate TRKB receptor activation by disrupting its interaction with the endocytic adaptor complex AP-2 
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UR  - http://hdl.handle.net/10138/313776 
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A1  - Fred, Senem Merve; Laukkanen, Liina; Brunello, Cecilia A.; Vesa, Liisa; Göös, Helka; Cardon, Iseline; Moliner, Rafael; Maritzen, Tanja; Varjosalo, Markku; Casarotto, Plinio C.; Castren, Eero 
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PB  -  
Y1  - 2019 
LA  - eng 
AB  - Several antidepressant drugs activate tropomyosin-related kinase B (TRKB) receptor, but it remains unclear whether these compounds employ a common mechanism for TRKB activation. Here, using MS, we found that a single intraperitoneal injection of fluoxetine disrupts the interaction of several proteins with TRKB in the hippocampus of mice. These proteins included members of adaptor protein complex-2 (AP-2) involved in vesicular endocytosis. The interaction of TRKB with the cargo-docking ? subunit ... 
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KW  - brain-derived neurotrophic factor (BDNF); clathrin; drug action; receptor tyrosine kinase; molecular pharmacology; neurotrophic receptor tyrosine kinase 2 (NTRK2); adaptor protein complex-2 (AP-2); neuroplasticity; NERVE GROWTH-FACTOR; NEUROTROPHIC FACTOR; RETROGRADE TRANSPORT; SURFACE EXPRESSION; SIGNALING PATHWAYS; PROTEOMIC ANALYSIS; PLASMA-MEMBRANE; AMPA RECEPTORS; CLATHRIN; TRAFFICKING; 1182 Biochemistry, cell and molecular biology; 3112 Neurosciences 
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