TY  -  
T1  - Phenotype-driven identification of epithelial signalling clusters 
SN  -  /  
UR  - http://hdl.handle.net/10138/233931 
T3  -  
A1  - Marques, Elsa; Peltola, Tomi; Kaski, Samuel; Klefstrom, Juha 
A2  -  
PB  -  
Y1  - 2018 
LA  - eng 
AB  - In metazoans, epithelial architecture provides a context that dynamically modulates most if not all epithelial cell responses to intrinsic and extrinsic signals, including growth or survival signalling and transforming oncogene action. Three-dimensional ( 3D) epithelial culture systems provide tractable models to interrogate the function of human genetic determinants in establishment of context-dependency. We performed an arrayed genetic shRNA screen in mammary epithelial 3D cultures to identify... 
VO  -  
IS  -  
SP  -  
OP  -  
KW  - PROTEIN INTERACTION NETWORKS; FALSE DISCOVERY RATE; CELL POLARITY; EXTRACELLULAR-MATRIX; TISSUE HOMEOSTASIS; RNA INTERFERENCE; TUMOR-SUPPRESSOR; BREAST-CANCER; HIPPO PATHWAY; TUMORIGENESIS; 3111 Biomedicine 
N1  -   
PP  -  
ER  -