TY  -  
T1  - Phosphorylation of NFATC1 at PIM1 target sites is essential for its ability to promote prostate cancer cell migration and invasion 
SN  -  /  
UR  - http://hdl.handle.net/10138/307010 
T3  -  
A1  - Eerola, Sini K; Santio, Niina M; Rinne, Sanni; Kouvonen, Petri; Corthals, Garry L; Scaravilli, Mauro; Scala, Giovanni; Serra, Angela; Greco, Dario; Ruusuvuori, Pekka; Latonen, Leena; Rainio, Eeva-Marja; Visakorpi, Tapio; Koskinen, Päivi J 
A2  -  
PB  - BioMed Central 
Y1  - 2019 
LA  - eng 
AB  - Abstract
              
                Background
                Progression of prostate cancer from benign local tumors to metastatic carcinomas is a multistep process. Here we have investigated the signaling pathways that support migration and invasion of prostate cancer cells, focusing on the role of the NFATC1 transcription factor and its post-translational modifications. We have previously identified NFATC1 as a substrate for the PIM1 kinase and shown that PIM1-dependent phosphorylation i... 
VO  -  
IS  -  
SP  -  
OP  -  
KW  - Prostate cancer; Metastatic carcinoma; NFATC1; PIM kinases; Cell motility 
N1  -   
PP  -  
ER  -