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T1  - Phylogeny-Aware Alignment with PRANK and PAGAN 
SN  -  /  
UR  - http://hdl.handle.net/10138/337258 
T3  - Methods in Molecular Biology 
A1  - Löytynoja, Ari 
A2  - Katoh, Kazutaka 
PB  - Humana press 
Y1  - 2021 
LA  - eng 
AB  - Evolutionary analyses require sequence alignments that correctly represent evolutionary homology. Evolutionary homology and proteins' structural similarity are not the same and sequence alignments generated with methods designed for structural matching can be seriously misleading in comparative and phylogenetic analyses. The phylogeny-aware alignment algorithm implemented in the program PRANK has been shown to produce good alignments for evolutionary inferences. Unlike other alignment programs, ... 
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KW  - 1182 Biochemistry, cell and molecular biology; Phylogeny-aware alignment; Evolutionary sequence analysis; Insertions and deletions; Character homology; MULTIPLE SEQUENCE ALIGNMENT; TREES; DISTANCE; ERRORS 
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