TY - T1 - Pili-like proteins of Akkermansia muciniphila modulate host immune responses and gut barrier function SN - / UR - http://hdl.handle.net/10138/178655 T3 - A1 - Ottman, Noora; Reunanen, Justus; Meijerink, Marjolein; Pietilä, Taija; Kainulainen, Veera; Klievink, Judith; Huuskonen, Laura; Aalvink, Steven; Skurnik, Mikael; Boeren, Sjef; Satokari, Reetta; Mercenier, Annick; Palva, Airi; Smidt, Hauke; de Vos, Willem M.; Belzer, Clara A2 - PB - Y1 - 2017 LA - eng AB - Gut barrier function is key in maintaining a balanced response between the host and its microbiome. The microbiota can modulate changes in gut barrier as well as metabolic and inflammatory responses. This highly complex system involves numerous microbiota-derived factors. The gut symbiont Akkermansia muciniphila is positively correlated with a lean phenotype, reduced body weight gain, amelioration of metabolic responses and restoration of gut barrier function by modulation of mucus layer thickne... VO - IS - SP - OP - KW - INTESTINAL EPITHELIUM; BACTEROIDES-FRAGILIS; ULCERATIVE-COLITIS; GEN. NOV.; IN-VITRO; MICROBIOTA; BACTERIA; MUCIN; MICE; ENTEROCYTES; 3111 Biomedicine N1 - PP - ER -