TY  -  
T1  - Polygenic Hyperlipidemias and Coronary Artery Disease Risk 
SN  -  /  
UR  - http://hdl.handle.net/10138/314469 
T3  -  
A1  - FinnGen Project; Ripatti, Pietari; Rämö, Joel T.; Mars, Nina J.; Fu, Yu; Lin, Jake; Söderlund, Sanni; Benner, Christian; Surakka, Ida; Kiiskinen, Tuomo; Havulinna, Aki S.; Palta, Priit; Freimer, Nelson B.; Widén, Elisabeth; Salomaa, Veikko; Tukiainen, Taru; Pirinen, Matti; Palotie, Aarno; Taskinen, Marja-Riitta; Ripatti, Samuli 
A2  -  
PB  -  
Y1  - 2020 
LA  - eng 
AB  - Background: Hyperlipidemia is a highly heritable risk factor for coronary artery disease (CAD). While monogenic familial hypercholesterolemia associates with severely increased CAD risk, it remains less clear to what extent a high polygenic load of a large number of LDL (low-density lipoprotein) cholesterol (LDL-C) or triglyceride (TG)-increasing variants associates with increased CAD risk. Methods: We derived polygenic risk scores (PRSs) with approximate to 6M variants separately for LDL-C and ... 
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KW  - 3111 Biomedicine; 1184 Genetics, developmental biology, physiology; 3121 General medicine, internal medicine and other clinical medicine; coronary artery disease; humans; hypercholesterolemia; hypertriglyceridemia; risk factors; DENSITY-LIPOPROTEIN CHOLESTEROL; FAMILIAL HYPERCHOLESTEROLEMIA; TRIGLYCERIDES; MUTATIONS; PLASMA 
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