TY - T1 - Polygenic Hyperlipidemias and Coronary Artery Disease Risk SN - / UR - http://hdl.handle.net/10138/314469 T3 - A1 - FinnGen Project; Ripatti, Pietari; Rämö, Joel T.; Mars, Nina J.; Fu, Yu; Lin, Jake; Söderlund, Sanni; Benner, Christian; Surakka, Ida; Kiiskinen, Tuomo; Havulinna, Aki S.; Palta, Priit; Freimer, Nelson B.; Widén, Elisabeth; Salomaa, Veikko; Tukiainen, Taru; Pirinen, Matti; Palotie, Aarno; Taskinen, Marja-Riitta; Ripatti, Samuli A2 - PB - Y1 - 2020 LA - eng AB - Background: Hyperlipidemia is a highly heritable risk factor for coronary artery disease (CAD). While monogenic familial hypercholesterolemia associates with severely increased CAD risk, it remains less clear to what extent a high polygenic load of a large number of LDL (low-density lipoprotein) cholesterol (LDL-C) or triglyceride (TG)-increasing variants associates with increased CAD risk. Methods: We derived polygenic risk scores (PRSs) with approximate to 6M variants separately for LDL-C and ... VO - IS - SP - OP - KW - 3111 Biomedicine; 1184 Genetics, developmental biology, physiology; 3121 General medicine, internal medicine and other clinical medicine; coronary artery disease; humans; hypercholesterolemia; hypertriglyceridemia; risk factors; DENSITY-LIPOPROTEIN CHOLESTEROL; FAMILIAL HYPERCHOLESTEROLEMIA; TRIGLYCERIDES; MUTATIONS; PLASMA N1 - PP - ER -