TY - T1 - Poststroke delivery of MANF promotes functional recovery in rats SN - / UR - http://hdl.handle.net/10138/252780 T3 - A1 - Mätlik, Kert; Anttila, Jenni E.; Kuan-Yin, Tseng; Smolander, Olli-Pekka; Pakarinen, Emmi; Lehtonen, Leevi; Abo-Ramadan, Usama; Lindholm, Päivi; Zheng, Congjun; Harvey, Brandon; Arumäe, Urmas; Lindahl, Maria; Airavaara, Mikko A2 - PB - Y1 - 2018 LA - eng AB - Stroke is the most common cause of adult disability in developed countries, largely because spontaneous recovery is often incomplete, and no pharmacological means to hasten the recovery exist. It was recently shown that mesencephalic astrocyte–derived neurotrophic factor (MANF) induces alternative or M2 activation of immune cells after retinal damage in both fruit fly and mouse and mediates retinal repair. Therefore, we set out to study whether poststroke MANF administration would enhance brain ... VO - IS - SP - OP - KW - 3111 Biomedicine; ISCHEMIC BRAIN-INJURY; CEREBRAL-ISCHEMIA; STROKE; EXPRESSION; DISEASE; PROTECTION; SYSTEM; MICE N1 - PP - ER -