TY  -  
T1  - Preferred SH3 Domain Partners of ADAM Metalloproteases Include Shared and ADAM-Specific SH3 Interactions 
SN  -  /  
UR  - http://hdl.handle.net/10138/160346 
T3  -  
A1  - Kleino, Iivari; Jarviluoma, Annika; Hepojoki, Jussi; Huovila, Ari Pekka; Saksela, Kalle 
A2  -  
PB  -  
Y1  - 2015 
LA  - eng 
AB  - A disintegrin and metalloproteinases (ADAMs) constitute a protein family essential for extracellular signaling and regulation of cell adhesion. Catalytic activity of ADAMs and their predicted potential for Src-homology 3 (SH3) domain binding show a strong correlation. Here we present a comprehensive characterization of SH3 binding capacity and preferences of the catalytically active ADAMs 8, 9, 10, 12, 15, 17, and 19. Our results revealed several novel interactions, and also confirmed many previ... 
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KW  - GROWTH-FACTOR RECEPTOR; ALTERNATIVE EXON USE; TEC FAMILY KINASES; CYTOPLASMIC DOMAIN; BREAST-CANCER; ECTODOMAIN CLEAVAGE; SIGNALING PATHWAYS; TRANSFORMED-CELLS; PROMOTE MIGRATION; TYROSINE KINASE; 3111 Biomedicine 
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ER  -