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T1  - Pregnancy induced TMA in severe preeclampsia results from complement-mediated thromboinflammation 
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UR  - http://hdl.handle.net/10138/331700 
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A1  - Lokki, A. Inkeri; Heikkinen-Eloranta, Jenni 
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Y1  - 2021 
LA  - eng 
AB  - Preeclampsia is a multifactorial vascular disease unique to human pregnancy. While genetic and antiangiogenic factors are important contributors to preeclampsia susceptibility, recent studies have shown that dysregulation and/or over-activation of the complement system has an integral role in dis-ease etiology. Furthermore, the role of the coagulation cascade may be underappreciated in the develop-ment of the disease. Traditionally, for research purposes, the pool of preeclampsia cases has been ... 
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KW  - Preeclampsia; Thromboinflammation; Thrombotic microangiopathy; Complement system; Pregnancy; CIRCULATING ANTIANGIOGENIC FACTORS; ENDOTHELIAL GROWTH-FACTOR; THROMBOTIC MICROANGIOPATHY; ANGIOGENIC FACTORS; FACTOR-H; TROPHOBLAST INVASION; ADAMTS13 ACTIVITY; MATERNAL KIR; ACTIVATION; RISK; 3123 Gynaecology and paediatrics 
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