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T1  - Preparation and characterization of multi-component tablets containing co-amorphous salts : Combining multimodal non-linear optical imaging with established analytical methods 
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UR  - http://hdl.handle.net/10138/308342 
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A1  - Ojarinta, Rami; Saarinen, Jukka; Strachan, Clare J.; Korhonen, Ossi; Laitinen, Riikka 
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Y1  - 2018 
LA  - eng 
AB  - Co-amorphous mixtures have rarely been formulated as oral dosage forms, even though they have been shown to stabilize amorphous drugs in the solid state and enhance the dissolution properties of poorly soluble drugs. In the present study we formulated tablets consisting of either spray dried co-amorphous ibuprofen-arginine or indomethacin-arginine, mannitol or xylitol and polyvinylpyrrolidone K30 (PVP). Experimental design was used for the selection of tablet compositions, and the effect of tabl... 
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KW  - Co-amorphous; Amino acid; Tablet; Deformation; Dissolution; Multimodal; non-linear imaging; CARS; SFG; SHG; WATER-SOLUBLE DRUGS; IBUPROFEN-POLYVINYLPYRROLIDONE DISPERSIONS; SOLID-STATE PROPERTIES; HOT-MELT EXTRUSION; AMINO-ACIDS; INDOMETHACIN-ARGININE; COMPACTION PROPERTIES; DISSOLUTION BEHAVIOR; DELIVERY SYSTEMS; MICROCRYSTALLINE CELLULOSE; 317 Pharmacy 
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