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T1  - Pro-cachectic factors link experimental and human chronic kidney disease to skeletal muscle wasting programs 
SN  -  /  
UR  - http://hdl.handle.net/10138/332421 
T3  -  
A1  - Solagna, Francesca; Tezze, C.; Lindenmeyer, M.T.; Lu, S.; Wu, G.; Liu, S.; Zhao, Y.; Mitchell, R.; Meyer, C.; Omairi, S.; Kilic, T.; Paolini, A.; Ritvos, O.; Pasternack, A.; Matsakas, A.; Kylies, D.; zur Wiesch, J.S.; Turner, J.-E.; Wanner, N.; Nair, V.; Eichinger, F.; Menon, R.; Martin, I.V.; Klinkhammer, B.M.; Hoxha, E.; Cohen, C.D.; Tharaux, P.-L.; Boor, P.; Ostendorf, T.; Kretzler, M.; Sandri, M.; Kretz, O.; Puelles, V.G.; Patel, K.; Huber, T.B. 
A2  -  
PB  -  
Y1  - 2021 
LA  - eng 
AB  - Skeletal muscle wasting is commonly associated with chronic kidney disease (CKD), resulting in increased morbidity and mortality. However, the link between kidney and muscle function remains poorly understood. Here, we took a complementary interorgan approach to investigate skeletal muscle wasting in CKD. We identified increased production and elevated blood levels of soluble pro-cachectic factors, including activin A, directly linking experimental and human CKD to skeletal muscle wasting progra... 
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IS  -  
SP  -  
OP  -  
KW  - 3121 General medicine, internal medicine and other clinical medicine; PERICYTE-MYOFIBROBLAST TRANSITION; ACTIVIN-A; CANCER CACHEXIA; MOLECULAR-MECHANISMS; II RECEPTORS; FIBROSIS; MASS; HOMEOSTASIS; SARCOPENIA; MYOSTATIN 
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ER  -