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T1  - Prognostic and diagnostic value of REG4 serum and tissue expression in pancreatic ductal adenocarcinoma 
SN  -  /  
UR  - http://hdl.handle.net/10138/299669 
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A1  - Saukkonen, K.; Hagström, J.; Mustonen, H.; Lehtinen, Laura; Carpen, O.; Andersson, L.C.; Seppänen, H.; Haglund, C. 
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Y1  - 2018 
LA  - eng 
AB  - Expression of regenerating islet-derived protein 4 (REG4), a secretory protein involved in cell differentiation and proliferation, is upregulated in inflammatory bowel diseases and in many gastrointestinal malignancies. The prognostic significance of its expression in pancreatic ductal adenocarcinoma is unknown. Our aim was to investigate tumor tissue and serum REG4 expression in pancreatic ductal adenocarcinoma patients. We also evaluated as a control the diagnostic value of serum REG4 level in... 
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KW  - pancreatitis associated protein; REG4 protein, human; tumor marker, adult; aged; biosynthesis; blood; chronic pancreatitis; differential diagnosis; female; human; immunohistochemistry; Kaplan Meier method; male; metabolism; middle aged; outcome assessment; pancreas carcinoma; pancreas tumor; procedures; prognosis; proportional hazards model; statistics and numerical data, Adult; Aged; Biomarkers, Tumor; Carcinoma, Pancreatic Ductal; Diagnosis, Differential; Female; Humans; Immunohistochemistry; Kaplan-Meier Estimate; Male; Middle Aged; Outcome Assessment (Health Care); Pancreatic Neoplasms; Pancreatitis, Chronic; Pancreatitis-Associated Proteins; Prognosis; Proportional Hazards Models; 3111 Biomedicine; 3122 Cancers 
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