TY  -  
T1  - Prolyl oligopeptidase inhibition by KYP-2407 increases alpha-synuclein fibril degradation in neuron-like cells 
SN  -  /  
UR  - http://hdl.handle.net/10138/322668 
T3  -  
A1  - Rostami, Jinar; Jäntti, Maria; Cui, Hengjing; Rinne, Maiju K.; Kukkonen, Jyrki P.; Falk, Anna; Erlandsson, Anna; Myöhänen, Timo 
A2  -  
PB  -  
Y1  - 2020 
LA  - eng 
AB  - Growing evidence emphasizes insufficient clearance of pathological alpha-synuclein (alpha SYN) aggregates in the progression of Parkinson's disease (PD). Consequently, cellular degradation pathways represent a potential therapeutic target. Prolyl oligopeptidase (PREP) is highly expressed in the brain and has been suggested to increase alpha SYN aggregation and negatively regulate the autophagy pathway. Inhibition of PREP with a small molecule inhibitor, KYP-2407, stimulates autophagy and reduces... 
VO  -  
IS  -  
SP  -  
OP  -  
KW  - Autophagy; Alpha-synuclein; Fibrils; Propagation; Calpain; Synucleinopathies; Neurodegeneration; PARKINSONS-DISEASE; FILAMENTOUS INCLUSIONS; PROTEIN-LEVELS; LEWY BODIES; ASTROCYTES; AUTOPHAGY; ENDOPEPTIDASE; PATHOLOGY; CLEAVAGE; CALPAIN; 317 Pharmacy 
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PP  -  
ER  -