TY  -  
T1  - Prolyl oligopeptidase inhibition reduces oxidative stress via reducing NADPH oxidase activity by activating protein phosphatase 2A 
SN  -  /  
UR  - http://hdl.handle.net/10138/330824 
T3  -  
A1  - Eteläinen, T.; Kulmala, Soile; Svarcbahs, R.; Jäntti, M.; Myohänen, T. T. 
A2  -  
PB  -  
Y1  - 2021 
LA  - eng 
AB  - Oxidative stress (OS) is a common toxic feature in various neurodegenerative diseases. Therefore, reducing OS could provide a potential approach to achieve neuroprotection. Prolyl oligopeptidase (PREP) is a serine protease that is linked to neurodegeneration, as endogenous PREP inhibits autophagy and induces the accumulation of detrimental protein aggregates. As such, inhibition of PREP by a small-molecular inhibitor has provided neuroprotection in preclinical models of neurodegenerative disease... 
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IS  -  
SP  -  
OP  -  
KW  - Oxidative stress; Neurodegeneration; Prolyl oligopeptidase; Protein phosphatase 2A; p47phox; NADPH oxidase; ALPHA-SYNUCLEIN; NEURODEGENERATIVE DISEASES; NRF2-ARE PATHWAY; TAU-PROTEIN; PARKINSONS; AGGREGATION; BRAIN; CELLS; CLEARANCE; ALZHEIMER; 1182 Biochemistry, cell and molecular biology; 317 Pharmacy 
N1  -   
PP  -  
ER  -