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T1  - Protection of dopamine neurons by CDNF and neurturin variant N4 against MPP+ in dissociated cultures from rat mesencephalon 
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UR  - http://hdl.handle.net/10138/333477 
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A1  - Jaumotte, Juliann D.; Saarma, Mart; Zigmond, Michael J. 
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PB  -  
Y1  - 2021 
LA  - eng 
AB  - Parkinson's disease is associated with the loss of dopamine (DA) neurons in ventral mesencephalon. We have previously reported that no single neurotrophic factor we tested protected DA neurons from the dopaminergic toxin 1-methyl-4-phenylpyridinium (MPP+) in dissociated cultures isolated from the P0 rat substantia nigra, but that a combination of five neurotrophic factors was protective. We now report that cerebral DA neurotrophic factor (CDNF) and a variant of neurturin (NRTN), N4, were also no... 
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KW  - NEUROTROPHIC FACTOR GDNF; PARTIAL LESION MODEL; CELL-LINE; SUBSTANTIA-NIGRA; PARKINSONS-DISEASE; TGF-BETA; PROMOTES TUMORIGENESIS; NIGROSTRIATAL SYSTEM; CHOLINERGIC NEURONS; PERSEPHIN PROMOTE; 1182 Biochemistry, cell and molecular biology 
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