TY - T1 - Protective Effects of Pituitary Adenylate Cyclase-Activating Polypeptide (PACAP) Against Oxidative Stress in Zebrafish Hair Cells SN - / UR - http://hdl.handle.net/10138/168484 T3 - A1 - Kasica, Natalia; Podlasz, Piotr; Sundvik, Maria; Tamas, Andrea; Reglodi, Dora; Kaleczyc, Jerzy A2 - PB - Y1 - 2016 LA - eng AB - Pituitary adenylate cyclase-activating polypeptide (PACAP) is a pleiotropic neuropeptide, with known antiapoptotic functions. Our previous in vitro study has demonstrated the ameliorative role of PACAP-38 in chicken hair cells under oxidative stress conditions, but its effects on living hair cells is now yet known. Therefore, the aim of the present study was to investigate in vivo the protective role of PACAP-38 in hair cells found in zebrafish (Danio rerio) sense organs-neuromasts. To induce ox... VO - IS - SP - OP - KW - PACAP; Apoptosis; Antioxidant; Hydrogen peroxide; Neuromast; Behavior; INDUCED HEARING-LOSS; PROTEIN-KINASE; INDUCED APOPTOSIS; INDUCED OTOTOXICITY; INNER-EAR; LATERAL-LINE; P38 MAPK; FREE-RADICALS; IN-VITRO; MITOCHONDRIAL DYSFUNCTION; 3112 Neurosciences; 3124 Neurology and psychiatry N1 - PP - ER -