TY - T1 - Protein misfolding in neurodegenerative diseases : implications and strategies SN - / UR - http://hdl.handle.net/10138/232927 T3 - A1 - Sweeney, Patrick; Park, Hyunsun; Baumann, Marc; Dunlop, John; Frydman, Judith; Kopito, Ron; McCampbell, Alexander; Leblanc, Gabrielle; Venkateswaran, Anjli; Nurmi, Antti; Hodgson, Robert A2 - PB - Y1 - 2017 LA - eng AB - A hallmark of neurodegenerative proteinopathies is the formation of misfolded protein aggregates that cause cellular toxicity and contribute to cellular proteostatic collapse. Therapeutic options are currently being explored that target different steps in the production and processing of proteins implicated in neurodegenerative disease, including synthesis, chaperone-assisted folding and trafficking, and degradation via the proteasome and autophagy pathways. Other therapies, like mTOR inhibitors... VO - IS - SP - OP - KW - Neurodegeneration; Proteostasis; Mouse models; Biomarkers; Chaperones; Drug discovery; UBIQUITIN-PROTEASOME SYSTEM; PRION-LIKE TRANSMISSION; HEAT-SHOCK RESPONSE; ALZHEIMERS-DISEASE; ALPHA-SYNUCLEIN; MOUSE MODELS; A-BETA; AMYLOID-BETA; HUNTINGTON DISEASE; QUALITY-CONTROL; 116 Chemical sciences; 3124 Neurology and psychiatry N1 - PP - ER -