TY  -  
T1  - Rabbit as an animal model for intravitreal pharmacokinetics : Clinical predictability and quality of the published data 
SN  -  /  
UR  - http://hdl.handle.net/10138/203409 
T3  -  
A1  - del Amo, Eva M.; Urtti, Arto 
A2  -  
PB  -  
Y1  - 2015 
LA  - eng 
AB  - Intravitreal administration is the method of choice in drug delivery to the retina and/or choroid. Rabbit is the most commonly used animal species in intravitreal pharmacokinetics, but it has been criticized as being a poor model of human eye. The critique is based on some anatomical differences, properties of the vitreous humor, and observed differences in drug concentrations in the anterior chamber after intravitreal injections. We have systematically analyzed all published information on intr... 
VO  -  
IS  -  
SP  -  
OP  -  
KW  - Ocular pharmacokinetics; Drug delivery; Intravitreal; Animal model; Rabbit; RETINAL-PIGMENT EPITHELIUM; ENDOTHELIAL GROWTH-FACTOR; MEDIATED DRUG DISPOSITION; INTRAOCULAR PHARMACOKINETICS; CYTOMEGALOVIRUS RETINITIS; NONVITRECTOMIZED EYES; MACULAR DEGENERATION; BLOOD-FLOW; POSTOPERATIVE ENDOPHTHALMITIS; OCULAR MICRODIALYSIS; 3125 Otorhinolaryngology, ophthalmology 
N1  -   
PP  -  
ER  -