TY  -  
T1  - Rapalogs can promote cancer cell stemness in vitro in a Galectin-1 and H-ras-dependent manner 
SN  -  /  
UR  - http://hdl.handle.net/10138/214063 
T3  -  
A1  - Posada, Itziar M. D.; Lectez, Benoit; Sharma, Mukund; Oetken-Lindholm, Christina; Yetukuri, Laxman; Zhou, Yong; Aittokallio, Tero; Abankwa, Daniel 
A2  -  
PB  -  
Y1  - 2017 
LA  - eng 
AB  - Currently several combination treatments of mTor- and Ras-pathway inhibitors are being tested in cancer therapy. While multiple feedback loops render these central signaling pathways robust, they complicate drug targeting. Here, we describe a novel H-ras specific feedback, which leads to an inadvertent rapalog induced activation of tumorigenicity in Ras transformed cells. We find that rapalogs specifically increase nanoscale clustering (nanoclustering) of oncogenic H-ras but not K-ras on the pla... 
VO  -  
IS  -  
SP  -  
OP  -  
KW  - mTORC1; Ras; rapamycin; galectin; cancer stem cells; K-RAS; MEMBRANE ORIENTATION; MTOR INHIBITORS; PROTEINS; TARGET; MODEL; HRAS; NANOCLUSTERS; METASTASIS; ACTIVATION; 3122 Cancers 
N1  -   
PP  -  
ER  -